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目的对比分析中药与奥沙西泮用于治疗高血压病患者睡眠障碍的临床疗效。方法收集2013年1月至2015年1月,我院收治的高血压伴睡眠障碍患者144例,随机分为观察组与对照组,72例每组。观察组予以中药辩证治疗,对照组予以用奥沙西泮治疗,对比两组的临床疗效。结果观察组治疗总有效率为97.22%,显著高于对照组的70.83%(χ2=24.013,P=0.000<0.05);治疗后两组的血压均较治疗前显著降低(P<0.05),组间比较无显著性差异(P>0.05);治疗第4d、8d及15d两组睡眠障碍量表(Sleep Dysfunction Rating Scale,SDRS)评分均显著降低,且观察组显著低于对照组(P<0.05);治疗第15d,两组的汉密尔顿焦虑量表(Hamilton Anxiety Scale,HAMA)及汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评分均显著降低,且观察组显著低于对照组(P<0.05);观察组的不良反应率为11.11%,显著低于对照组的43.06%(χ2=24.252,P=0.000<0.05)。结论中医药对症治疗高血压伴睡眠障碍疗效优于奥沙西泮,能够更好地改善患者的睡眠状态,且不良反应较少,值得在临床中推广应用。
Objective To compare the clinical efficacy of traditional Chinese medicine and oxazepam in the treatment of sleep disorders in hypertensive patients. Methods From January 2013 to January 2015, 144 patients with hypertension and sleep disorders admitted to our hospital were randomly divided into observation group and control group, and 72 patients in each group. The observation group was given dialectical treatment of traditional Chinese medicine, and the control group was treated with oxazepam. The clinical efficacy was compared between the two groups. Results The total effective rate in the observation group was 97.22%, which was significantly higher than that in the control group (χ2 = 24.013, P = 0.000 <0.05). After treatment, the blood pressure in both groups was significantly lower than that before treatment (P <0.05) There was no significant difference between the two groups (P> 0.05). The Sleep Dysfunction Scale (SDRS) score of the 4th, 8th and 15th days in the treatment group was significantly lower than that in the control group (P <0.05) ). On the 15th day after treatment, the scores of Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) in both groups were significantly decreased, and the observation group was significantly lower than the control group (P <0.05) The rate of adverse reactions in the observation group was 11.11%, which was significantly lower than that in the control group (χ2 = 24.252, P = 0.000 <0.05). Conclusion Chinese medicine symptomatic treatment of hypertension with sleep disorders better than oxazepam, can better improve the patient’s sleep state, and fewer adverse reactions, it is worth in the clinical application.