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为测定烧伤对有效或营养性的肝脏血流的影响,以及血流与氧化物引起的脂质过氧化的关系,用45～55kg成年绵羊31头,经颈部切口行主动脉、中心静脉和肺动脉插管,术后至少3天使动物恢复至稳定状态。10头对照动物在麻醉后4～5小时测定肝血流,21头与对照组同样测定有效肝血流,俟其清醒3天后再次麻醉,造成体表面积40％Ⅲ°烧伤。伤后15分钟内开始液体复苏,在恢复并维持心室灌注压和心输出量处于基线值的前提下,7头动物单纯应用乳酸林格液;7头加用5％羟乙基淀粉溶
In order to determine the effect of burns on the hepatic blood flow, which is effective or nutritious, and the relationship between blood flow and lipid peroxidation induced by oxidants, 31 heads of 45 ~ 55 kg adult sheep were divided into three groups: aorta, central vein and Pulmonary artery catheterization, the animals recovered to a stable state at least 3 days after surgery. Twenty control animals were tested for hepatic blood flow 4 to 5 hours after anesthesia. Twenty-one of them were also tested for effective hepatic blood flow in the same way as the control group. After 3 days of awake, they were re-anesthetized, resulting in a 40% body surface area burn. Fluid resuscitation started within 15 minutes after injury. Seven animals were treated with lactated Ringer’s solution alone. Seven animals were treated with 5% hydroxyethyl starch