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目的观察奥曲肽联合雷贝拉唑在非静脉曲张性上消化道出血中的临床效果。方法 2011年5月—2013年10月接受治疗的非静脉曲张性上消化道出血患者162例,随机分为对照组与观察组各81例。对照组雷贝拉唑40 mg与100 ml生理盐水混合后静脉滴注,2次/d;观察组先以奥曲肽0.1 mg静脉注射,然后将奥曲肽0.3 mg与120 ml生理盐水混合后微量泵入。两组均连续治疗2 d。观察两组治疗期间的止血时间和输血量。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果观察组止血时间短于对照组[(20.4±4.4)h]、输血量[(1.2±0.4)U]少于对照组,两组比较差异有统计学意义(P<0.05)。对照组总有效率77.78%,观察组总有效率95.06%,两组比较差异有统计学意义(χ2=10.309,P<0.05)。结论在非静脉曲张性上消化道出血的治疗中应用奥曲肽与雷贝拉唑联合治疗能够缩短止血时间、降低输血量、提高止血有效率,可作为非静脉曲张性上消化道出血治疗的首选措施,值得临床推广。
Objective To observe the clinical effect of octreotide combined with rabeprazole in non-variceal upper gastrointestinal bleeding. Methods 162 patients with non-variceal upper gastrointestinal bleeding treated from May 2011 to October 2013 were randomly divided into control group and observation group with 81 cases each. The control group rabeprazole 40 mg with 100 ml of normal saline mixed intravenous infusion, 2 times / d; observation group first with octreotide 0.1 mg intravenous injection, and then octreotide 0.3 mg mixed with 120 ml of saline and then a small amount of pumped. Two groups were treated for 2 days. Hemostatic time and blood transfusion during the two groups were observed. Measurement data were compared using t test, count data were compared using χ2 test, P <0.05 for the difference was statistically significant. Results The bleeding time in the observation group was shorter than that in the control group [(20.4 ± 4.4) h], and the transfusion volume was (1.2 ± 0.4) U less than the control group. There was significant difference between the two groups (P <0.05). The total effective rate was 77.78% in the control group and 95.06% in the observation group. There was significant difference between the two groups (χ2 = 10.309, P <0.05). Conclusions The combination of octreotide and rabeprazole in the treatment of non-variceal upper gastrointestinal hemorrhage can shorten the time of hemostasis, reduce blood transfusion and improve the effective rate of hemostasis, which can be the first choice for the treatment of non-variceal upper gastrointestinal bleeding , It is worth clinical promotion.