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早产约占分娩的10%,妊娠30周以前出生婴儿或体重1000克以下未成熟儿的管理问题很多,解决好此问题的关键是预防早产。先兆早产的原因大部分由于早期宫缩,因此,如何选择抑制宫缩,且对孕妇及胎儿副作用少的药物,是很重要的。目前,日本常用盐酸苯氧苯丙酚胺和二苯哌酯,在副作用和效果上尚有问题。对象及方法:1980年5月至1984年12月,对大分医科大学产科住院的无心疾病、糖尿病、肾肝疾病等合并症的21例先兆早产,静脉点入羟苄羟麻黄碱连续7天以上,羟苄羟麻黄碱(50mg/5ml 安瓿)以生理盐水或葡萄糖500ml 溶解后静脉输入,浓度由50μg/分开始,以后每隔30分增加50μg/分,直增至抑制宫缩为止,原则上
Premature birth accounts for about 10% of deliveries, babies born before 30 weeks of gestation or immature babies weighing less than 1000 grams have many management problems. The key to solving this problem is to prevent premature birth. Most of the causes of threatened preterm birth due to early contractions, so how to choose to inhibit contractions, and pregnant women and fetuses less side effects of drugs, is very important. Currently, phenoxyphenamine hydrochloride and diphenoxylate hydrochloride commonly used in Japan are still problematic in side effects and effects. PARTICIPANTS AND METHODS: From May 1980 to December 1984, 21 patients with comorbidities, diabetes mellitus, and kidney and liver diseases inpatient obstetrics and gynecology hospital, Oita Medical College were enrolled in this study. 21 cases of preterm labor were induced by intravenous injection of oxybenzone for 7 days , Hydroxybenzidipine (50mg / 5ml ampoule) dissolved in saline or dextrose 500ml after intravenous infusion, the concentration from 50μg / min start, then every 30 minutes increased 50μg / min, straight to suppress contractions, in principle