对新抗生素B-3543进行了系统的研究,关键指标已达到工业化生产水平。确立了产生菌的分类地位,测定了抗生素的抗菌谱,获得效价达10000μg/ml的高产菌株,阐明了B-3543的化学结构,提出3种效价检定方法,制定了产品质量标准,完善了生产工艺,使产品总收率达60％。该项目还存在产品成本过高,产品稳定性不好等问题,有待研究解决。 The new antibiotic B-3543 has been systematically studied, and the key indicators have reached the level of industrial production. The antibacterial spectrum of antibiotics was determined, the high-yielding strain with the titer of 10000μg / ml was obtained, the chemical structure of B-3543 was clarified, three potency test methods were proposed, the product quality standards were established, The production process, the total product yield of 60%. The project also exists the problem of too high product cost and poor product stability, which needs to be studied and solved.