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目的:探讨ADVIA 2120血液分析仪在儿童异型淋巴细胞检测中的临床应用价值。方法:选取中山市博爱医院在2014年10月到2016年10月通过ADVIA 2120血液分析仪测定存在异型淋巴细胞报警信息提示和不存在有异型淋巴细胞的300例儿童外周血样本作研究对象,将所有样本进行人工复检。结果:ADVIA 2120血液分析仪对儿童异型淋巴细胞临床检测的敏感度为93.5%,其特异度为88.4%,阳性预测值为89.4%,阴性预测值为92.8%。与显微镜检测结果相比差异无统计学意义(P>0.05)。结论:临床上采用ADVIA 2120血液分析仪对异型淋巴细胞进行检测具有较高的灵敏度,但是假阳性率偏高,因此,ADVIA 2120血液分析仪在儿童异型淋巴细胞检测多中可作为一个有效的初筛工具,但是仍需要人工显微镜复检。
Objective: To investigate the clinical value of ADVIA 2120 hematology analyzer in detecting atypical lymphocytes in children. Methods: From March 2014 to October 2016, Bo’ai Hospitals of Zhongshan City, Guangdong Province, China, 300 children with peripheral blood samples of 300 cases of allogeneic lymphocytes were analyzed by ADVIA 2120 hematology analyzer. All samples were manually reviewed. Results: The sensitivity of the ADVIA 2120 hematology analyzer for clinical detection of childhood atypical lymphocytes was 93.5% with a specificity of 88.4%, a positive predictive value of 89.4% and a negative predictive value of 92.8%. Compared with the results of microscopy, there was no significant difference (P> 0.05). CONCLUSIONS: ADVIA 2120 hematology analyzer is clinically useful for the detection of atypical lymphocytes with high sensitivity, but with a high false-positive rate. Therefore, the ADVIA 2120 hematology analyzer can be used as a potent early detection reagent for childhood atypical lymphocytes Screening tools, but still require manual microscopy review.