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服用呋喃硝胺的病人约有3%出现头痛、皮疹和头晕等轻微副作用,发生严重的毒性则罕见。本文报告1例发生肝炎。一位77岁的妇人因寒战、发热和偶尔呕吐入院。12天前服用呋喃硝胺治疗活动性消化性溃疡,150mg每日2次。服药后有进行性全身不适和厌食。过去无肝病、输血、接触黄疸病人以及应用其它药物或饮酒等病史,有青霉素过敏史。体检:38.3℃,未见黄疸、慢性肝病征和肝脾肿大。血清谷草和谷丙转氨
Approximately 3% of patients taking nitrofuranton have minor side effects such as headache, rashes, and dizziness, and severe toxicity is rare. This article reports 1 case of hepatitis. A 77-year-old woman was hospitalized for chills, fever and occasional vomiting. 12 days ago taking ranitidine treatment of active peptic ulcer, 150mg twice daily. After taking progressive general malaise and anorexia. In the past no liver disease, blood transfusions, contact with patients with jaundice and other medical or drinking history, penicillin allergy history. Physical examination: 38.3 ℃, no jaundice, chronic liver disease and hepatosplenomegaly. Serum glutamic acid and alanine