用东茛菪硷抢救急性有机磷农药中毒（ＡＯＩＰ）４４５例，其中轻度６１例、中度１４５例、重度２３９例。死亡６例，治愈４３９例，总治愈率为９８．７％，重度病人死亡率为２．５１％。本资料表明，东茛菪硷能较快地达茛菪硷化，有效地防治呼吸衰竭、Ｑ—Ｔ间期延长等并发症，减少反跳、缩短住院时间、降低死亡率。对其作用机理作了探讨。 445 cases of acute organophosphorus pesticide poisoning (AOIP) were treated with scopolamine, of which 61 were mild, 145 were moderate and 239 were severe. 6 died, 439 cases cured, the total cure rate was 98.7%, severe patient mortality was 2.51%. This data shows that Scopolamine can quickly scopolamine alkalization, effective prevention and treatment of respiratory failure, Q-T interval prolongation and other complications, reduce rebound, reduce hospital stay and reduce mortality. The mechanism of action is discussed.