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近年国外发现了一类称作为组胺 H_2—受体拮抗药(Histamine H_2—receptor anta-gonists)或 H_2—受体阻断药(H_2—receptorblockers)的新药。这一进展对组胺在许多生理、病理过程中的作用有了新的研究工具,对十二指肠溃疡等疾病有了新的治疗手段,本文就这类药物的发展经过,及其代表药物甲咪氰胍的药理作用和临床应用综述如下。一、H_2—受体阻断药的发展经过1910年 Dale 等从麦角中分离出组胺,并且阐明它具有使肠段收缩、血压下降等作用。此后又经过半个多世纪的努力,认识到组
In recent years, a group of new drugs have been discovered abroad as Histamine H 2 -receptor anta-gonists or H 2 -receptor blockers. This progress has many new research tools on the role of histamine in many physiological and pathological processes and new treatments for diseases such as duodenal ulcer. In this paper, the development of such drugs and their representative drugs The pharmacological effects and clinical application of mecamylamine are summarized as follows. First, the development of H 2 -receptor blocker After 1910 Dale from the ergot isolated histamine, and clarified it has the intestine contraction, blood pressure and other effects. Since then, after more than half a century of efforts, recognize the group