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目的考察止痹痛巴布剂体内外透皮给药的相关性。方法体外试验采用单室扩散池,HPLC法检测接收池中青藤碱的质量浓度;体内试验检测大鼠的血药浓度,采用W-N法计算累积吸收质量浓度。对体外累积透过质量浓度与体内累积吸收质量浓度进行线性回归。结果回归方程为Y=0.097 24 X+0.323 91,r=0.955 1,体内外相关性非常显著(α=0.001)。结论此方法可用于评价透皮给药系统体内外的相关性。
Objective To investigate the correlation between Zhitong Tong poultice in vitro and in vivo. Methods The single ventricular diffusion cell and the HPLC method were used to determine the concentration of sinomenine in the receiving cell in vitro. The concentration of sinomenine in the receiving cell was determined by in vivo test. The cumulative absorption mass concentration was calculated by W-N method. A linear regression was performed on the cumulative permeate mass concentration in vitro and the cumulative mass concentration absorbed in the body. Results The regression equation was Y = 0.097 24 X + 0.323 91, r = 0.955 1, the correlation was significant in vitro and in vivo (α = 0.001). Conclusion This method can be used to evaluate the in vivo and in vitro relevance of transdermal drug delivery systems.