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目的：探讨金黄色葡萄球菌（金葡菌）Ｌ型对Ｗｉｓｔａｒ大鼠（二级）的致病作用，观察实验动物病理学变化。方法：经鼠尾静脉注射金葡菌Ｌ型菌液，１５天处死实验动物，大体和光镜观察。结果：实验组大鼠之心、肺、肝、肾和脑呈现不同程度的肿胀、淤血、出血，组织细胞变性坏死，单核巨噬细胞浸润，无明显中性白细胞。结论：金葡菌Ｌ型经血感染Ｗｉｓｔａｒ大鼠，可导致其主要脏器、细胞损伤，形成局部脏器间质性炎改变。
Objective: To investigate the pathogenicity of Staphylococcus aureus L-form to Wistar rats (secondary) and to observe the pathological changes of experimental animals. Methods: Staphylococcus aureus L-type bacterial fluid was injected into tail vein of mice and the experimental animals were killed 15 days later. Results: The heart, lung, liver, kidney and brain in experimental group showed varying degrees of swelling, congestion, hemorrhage, degeneration and necrosis of tissue cells, infiltration of monocytes and macrophages without obvious neutrophils. Conclusion: Staphylococcus aureus infection of Wistar rats with L-type menstrual blood can lead to the damage of its major organs and cells and the formation of local organ interstitial inflammation.