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目的:研究乳腺癌组织中CD44v6和E-Cadherin的表达,探讨其表达与乳腺癌各临床病理特征之间的关系,分析CD44v6及E-Cadherin表达之间的相关性。方法:应用免疫组织化学染色方法(SP法)检测75例乳腺癌组织、40例癌旁乳腺组织、20例正常乳腺组织中CD44v6、E-Cadherin的表达,分析其表达与临床病理学特征的关系以及CD44v6与E-Cadher-in表达的相关性。结果:E-Cadherin表达率乳腺癌组织<正常乳腺组织(P<0.01)、癌肿>2 cm者<癌肿<2 cm者(P<0.01);Ⅲ期乳腺癌<Ⅱ期乳腺癌<Ⅰ期乳腺癌(P<0.05);有淋巴结转移者<无淋巴结转移者(P<0.05)。CD44v6表达率乳腺癌组织>正常乳腺组织(P<0.01)、癌肿>3 cm者>癌肿<3 cm者(P<0.01);Ⅲ期乳腺癌>Ⅱ期乳腺癌>Ⅰ期乳腺癌(P<0.05);有淋巴结转移者>无淋巴结转移者(P<0.05)。CD44v6与E-Cadherin之间存在负相关。结论:CD44v6及E-Cadherin表达水平与乳腺癌临床分期、淋巴结转移、组织分化程度相关,两者之间的关系密切。联合检测可能对乳腺癌的辅助诊断具有一定的临床意义。
OBJECTIVE: To investigate the expression of CD44v6 and E-Cadherin in breast cancer tissues, and to explore the relationship between the expression of CD44v6 and clinicopathological features in breast cancer and the correlation between the expression of CD44v6 and E-Cadherin. Methods: The expressions of CD44v6 and E-Cadherin in 75 cases of breast cancer tissues, 40 cases of paracancer tissues and 20 cases of normal breast tissues were detected by immunohistochemical staining (SP method), and their relationship with clinicopathological features was analyzed And the correlation between CD44v6 and E-Cadher-in expression. Results: The expression of E-Cadherin in breast cancer tissues was lower than that in normal breast tissues (P <0.01), cancer> 2 cm (<2 cm) (P <0.01) Stage breast cancer (P <0.05); those with lymph node metastasis 3 cm (P <0.01), stage Ⅲ breast cancer (P <0.01) P <0.05); those with lymph node metastasis> those without lymph node metastasis (P <0.05). There is a negative correlation between CD44v6 and E-Cadherin. Conclusion: The expressions of CD44v6 and E-Cadherin are closely related to the clinical stage, lymph node metastasis and histological differentiation of breast cancer. Joint detection may have some clinical significance in the diagnosis of breast cancer.