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目的 比较不同喂养方式对 HBs Ag阳性母亲的婴儿母婴传播阻断效果的影响。 方法 HBs Ag阳性母亲的婴儿常规接种乙型肝炎疫苗或接受乙型肝炎疫苗和乙型肝炎免疫球蛋白联合免疫并随访。6 2例婴儿单用乙型肝炎疫苗免疫 ,2 1例母乳喂养 ,41例人工喂养 ;16 8例婴儿联合免疫 ,33例母乳喂养 ,135例人工喂养。 结果 单用疫苗时 1、3、6、12月龄抗 - HBs阳性率母乳喂养组分别为 4.8%、42 .9%、5 7.9%、80 .9% ,人工喂养组分别为 12 .2 %、2 6 .3%、6 0 .5 %、73.2 % ;联合免疫时 1、4、7、12月龄抗 - HBs阳性率母乳喂养组分别为 72 .7%、75 .8%、77.4%、90 .9% ,人工喂养组为77.0 %、72 .9%、76 .2 %、90 .4%。单用疫苗时 ,母乳喂养组 1例、人工喂养组 3例免疫失败 ;联合免疫时 ,母乳喂养组无一例免疫失败 ,人工喂养组 4例免疫失败 ,母乳喂养和人工喂养比较 ,差异均无显著性。 结论 母乳喂养不影响抗 - HBs产生 ,不增加免疫失败。
Objective To compare the effects of different feeding methods on the blocking of mother-to-infant transmission of HBsAg-positive mothers. Methods Infants of HBsAg-positive mothers were routinely vaccinated with hepatitis B or hepatitis B and hepatitis B immunoglobulin co-immunization and follow-up. 62 were immunized with hepatitis B vaccine alone, 21 were breastfed and 41 were fed artificially; 168 were immunized with infants, 33 were breastfed and 135 were fed artificially. Results single vaccine 1, 3, 6, 12 month-old anti - HBs positive rate of 4.8% breastfed respectively, 42.9%, 57.9% 80.9%, artificial feeding group were 12.2% , 26.3%, 60.5% and 73.2%, respectively. The rates of anti-HBs positive breastfeeding at 1, 4, 7 and 12 months of combined immunization were 72.7%, 75.8% and 77.4% , 90.9%, artificial feeding group was 77.0%, 72.9%, 76.2%, 90.4%. Single vaccine, group 1 patients breast, artificial feeding group 3 patients immune failure; when combined immunization, none breastfed immune failure, Cade 4 patients immune failure, and artificial breast feeding, the difference was significant Sex. Conclusion Breastfeeding does not affect anti-HBs production, and does not increase immune failure.