本世纪50年代以来,随着电子显微镜分辨能力的提高,以及超薄切片的使用,电子显微镜愈来愈多地被应用来观察正常细胞及病理细胞内微细结构的变化,在肿瘤病理学研究方面亦得到广泛开展。一系列研究工作使我们对肿瘤细胞形态学的知识从光学显微镜水平提高到亚显微结构水平。在肿瘤病理学的研究范围内,很早就开始了对肿瘤病因学的研究,这方面的工作着重在努力发现肿瘤细胞内的病毒颗粒。很多动物的肿瘤细胞内,如鸡肉瘤、兔乳头状瘤、兔纤维 Since the 1950s, with the improvement of the resolving power of electron microscopy and the use of ultra-thin sections, electron microscopes have been increasingly used to observe changes in the fine structure of normal cells and pathological cells, in terms of tumor pathology. It has also been widely carried out. A series of research work has enabled us to improve the knowledge of tumor cell morphology from the level of light microscopy to the level of sub-microscopic structures. Within the scope of the study of tumor pathology, the study of the etiology of tumors began very early. The work in this area focuses on the discovery of viral particles in tumor cells. Many animal tumor cells, such as chicken sarcoma, rabbit papilloma, rabbit fiber