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背景:硒是人体必需的微量元素之一,是具有抗氧化功能的硒酶的活性中心,能清除体内的自由基,有效地催化有害的过氧化物还原为无害的羟基化合物,增强人体免疫力,预防和治疗心脑血管疾病和癌症。目的:比较心脑血管疾病患者血硒水平与健康者的差别,以期对心脑血管疾病的预防和治疗提供依据。设计:病例-对照分析。单位:大连铁路卫生学校,大连铁路医院,大连铁道学院应化系。对象:采集2000-03/2001-05大连铁路医院收治的心脑血管疾病患者血样319份。319例患者中男169例,女150例;高血压164例,冠状动脉粥样硬化性心脏病97例,心律失常41例,脑血管意外17例。健康组300例为同期健康体检者,男159例,女141例。方法:用新极谱法测定心脑血管疾病患者血样的血硒水平。主要观察指标:①两组受试者血硒的总体水平。②不同性别血硒水平比较。③患者组不同病种间血硒水平比较。结果:619例受试者全部进入结果分析。①患者组总体血硒水平低于健康组[(114.0±52.5),(146.5±51.0)μg/L,P<0.001],仅为健康人的76%。②男性与女性血硒含量的概率分布均为正态分布,男女之间差异无显著性意义(P>0.10),但血硒水平女性略高于男性。③高血压、冠状动脉粥样硬化性心脏病、心律失常患者血硒水平相当于健康组的82.7%,68.6%,66.0%,但男女之间差异不显著(P>0.10)。脑血管意外患者的血硒水平最低,为(84.4±28.9)μg/L,仅是健康人的57.6%。结论:心脑血管疾病患者血硒水平低于健康人,应适量补充有机硒和无机硒。
BACKGROUND: Selenium is one of the trace elements essential to the human body and is an active center of selenium enzyme with anti-oxidant function. It can eliminate free radicals in the body and effectively catalyze the reduction of harmful peroxides to harmless hydroxyl compounds, thereby enhancing human immunity Force, prevention and treatment of cardiovascular and cerebrovascular diseases and cancer. OBJECTIVE: To compare the differences of selenium levels and healthy subjects in patients with cardiovascular and cerebrovascular diseases in order to provide evidences for the prevention and treatment of cardiovascular and cerebrovascular diseases. Design: Case-control analysis. Unit: Dalian Railway Health School, Dalian Railway Hospital, Dalian Railway Institute Department of Chemistry. PARTICIPANTS: A total of 319 blood samples were collected from patients with cardiovascular and cerebrovascular diseases admitted to Dalian Railway Hospital from March 2000 to March 2001. There were 169 males and 150 females in 319 cases, 164 cases of hypertension, 97 cases of coronary atherosclerotic heart disease, 41 cases of arrhythmia and 17 cases of cerebrovascular accident. Health group 300 cases for the same period health examination, 159 males and 141 females. Methods: The blood levels of selenium in patients with cardiovascular and cerebrovascular diseases were determined by the new polarographic method. MAIN OUTCOME MEASURES: ① The overall level of blood selenium in two groups of subjects. ② different levels of blood selenium levels. ③ patients in different groups of selenium blood levels were compared. Results: 619 subjects all entered the result analysis. ① The overall selenium level in the patients group was lower than that in the healthy group [(114.0 ± 52.5), (146.5 ± 51.0) μg / L, P <0.001], only 76% of the healthy subjects. ② The distribution of selenium in blood of both men and women were normal distribution, there was no significant difference between men and women (P> 0.10), but selenium level of blood was slightly higher than that of men. ③Hypertension, coronary atherosclerotic heart disease, blood selenium levels in patients with arrhythmia were 82.7%, 68.6%, 66.0% in healthy group, but there was no significant difference between men and women (P> 0.10). Patients with cerebrovascular accident had the lowest blood selenium level (84.4 ± 28.9 μg / L), only 57.6% of healthy people. CONCLUSION: Blood selenium levels in patients with cardiovascular and cerebrovascular diseases are lower than those in healthy people, and organic selenium and inorganic selenium should be supplemented by the appropriate amount.