论文部分内容阅读
目的 研究胃黏膜相关淋巴组织淋巴瘤 (MALTL)bcl -2、p5 3蛋白和PCNA的表达及其临床意义。方法 采用免疫组化的方法检测 2 6例胃MALTL组织中bcl -2、p5 3和PCNA蛋白表达情况。结果 胃MALTL主要为B淋巴细胞来源 ,胃MALTLbcl -2阳性率为 42 % ,与组织学分级、临床分期等无关 ;p5 3阳性率为 3 8% ,与病理组织学分级呈正相关 (P =0 .0 0 1) ,与临床分期无关 ;PCNA的阳性细胞百分数为 10 %～ 95 % [(66± 2 8) % ] ,其百分数与病理组织学分级、临床分期无关。结论 p5 3蛋白的表达与胃MALTL的组织学分级有密切关系 ,而bcl -2蛋白和PCNA与病理组织学分级、临床分期无关
Objective To study the expression of bcl-2, p5 3 protein and PCNA in gastric mucosa-associated lymphoid tissue lymphoma (MALTL) and their clinical significance. Methods Immunohistochemistry was used to detect the expression of bcl-2, p5 3 and PCNA in 26 gastric MALTL tissues. Results The gastric MALTL mainly originated from B lymphocytes. The positive rate of gastric MALTLbcl -2 was 42%, which was not related to the histological grade, clinical stage, etc. The positive rate of p5 3 was 38%, which was positively correlated with histological grade (P = 0 .0 0 1). The percentage of PCNA positive cells was 10% -95% [(66 ± 28)%]. The percentage of PCNA positive cells was not related to the pathological grade and clinical stage. Conclusion The expression of p53 protein is closely related to the histological grade of gastric MALTL, while the expression of bcl-2 protein and PCNA is not related to the pathological grade and clinical stage