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安定溶液给儿童直肠应用后几分钟就可获得血清峰浓度。本文研究成人直肠用药的吸收。6例神经科成年病人,多年患严重头痛、接受安定注射剂(静脉和肌内注射)与直肠滴注溶液,剂量均为10mg。用药前至少二周不用安定类或其他药物制剂。血样采集:用药前以及用药后于5、10、15、20、30与60分钟以及2、3、4、8、24小时由前臂静脉抽取血样,待血凝后离心分出血清。用气相层析法测血清安定浓度与代谢物去甲安定的血清浓度。研究结果表明,直肠滴注安定溶液后10~20分钟
Serum peak concentrations can be obtained within minutes after diazepam is given to children for rectal use. This article studies the absorption of adult rectal medication. Six adult neurological patients, suffering from severe headache for many years, receiving stable injection (intravenous and intramuscular injection) and rectal infusion solution, the dose was 10mg. At least two weeks before treatment without stability class or other pharmaceutical preparations. Blood samples: Blood samples were drawn from the forearm vein at 5, 10, 15, 20, 30 and 60 minutes, and at 2, 3, 4, 8, and 24 hours before and after treatment. Serum concentration of diazepam and its metabolites were determined by gas chromatography. The results show that rectal infusion of diazepam solution after 10 to 20 minutes