一氧化氮不仅通过一氧化氮合成酶(nitric oxide synthases,NOS)由L-精氨酸合成,还可由其惰性代谢物,亚硝酸盐和硝酸盐合成。绿叶蔬菜中含有丰富的硝酸盐。但是膳食中亚硝酸盐/硝酸盐的缺乏是否导致疾病的发生还有待澄清。该研究人员假设,喂食中长期缺乏亚硝酸盐/硝酸盐会诱导小鼠发生代谢综合征。方法:制备以氨基酸为基础,低亚硝酸盐/硝酸盐含量(low-nitrite/nitrate diet,LND)饲料,其中L-精氨 Nitric oxide is synthesized not only from L-arginine by nitric oxide synthases (NOS), but also from its inert metabolites, nitrites and nitrates. Green leafy vegetables are rich in nitrate. However, whether the lack of nitrite / nitrate in the diet leads to the occurrence of the disease remains to be clarified. The researchers hypothesized that feeding mid to long term nitrite / nitrate would induce metabolic syndrome in mice. Methods: Amino acid-based, low-nitrite / nitrate diet (LND) feed was prepared, in which L-arginine