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目的:比较舒马曲坦注射剂与麦角胺咖啡因片剂治疗偏头痛的疗效。方法:72例偏头痛病人分为2组,舒马曲坦组40例(男性4例,女性36例;年龄40a±s15a)用舒马曲坦6mg,sc;麦角胺咖啡因组32例(男性6例,女性26例;年龄39a±16a),口服麦角胺咖啡因2片。结果:用药2h后,舒马曲坦组和麦角胺咖啡因组完全缓解率分别为70%和31%,总缓解率为88%和50%(P<0.01)。用药15min至2h,舒马曲坦组缓解率、起效速度均明显优于麦角胺咖啡因组,15min和2h时分别为25%和6%,88%和50%,(P<0.01)。2组不良反应均轻微短暂。结论:舒马曲坦注射剂治疗偏头痛优于麦角胺咖啡因片剂。
OBJECTIVE: To compare the efficacy of sumatriptan injection and ergotamine caffeine tablet in the treatment of migraine. Methods: A total of 72 patients with migraine were divided into two groups, 40 patients (4 males and 36 females; age 40a ± s15a) were treated with sumatriptan 6mg, sc; ergotamine caffeine (n = 32) 6 males and 26 females; age 39a ± 16a), 2 tablets of ergotamine caffeine. Results: The complete remission rates of sumatriptan group and ergotamine caffeine group were 70% and 31%, respectively, and the total remission rates were 88% and 50% (P <0.01) after 2 hours. The rates of remission and onset of action in sumatriptan group were significantly better than those in ergotamine group during 15min to 2h, 25% and 6%, 88% and 50% respectively at 15min and 2h (P <0.01) ). Adverse reactions in both groups were mild and transient. Conclusion: Sumatriptan injection is superior to ergotamine caffeine in the treatment of migraine.