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鼠同种异体和同系妊娠过程中,在妊娠的中期和晚期时,母体的脾和子宫引流淋巴结(PALN)重量增加,同时这些器官中的“基础”免疫球蛋白(Ig)分泌细胞数也增高,脾脏中的增高于妊娠16天时达到高峰,PALN 中18～19天达高峰。母体“基础”Ig 分泌增高是由于母体激素和或来自胎儿或胎盘的可溶性因子诱导的。假孕试验证实单用母体激素不能解释这种增高。作者早期试验已证实胎盘对母体 Ig 合成有重要调节作用。较晚期妊娠中,脾及派伊尔结(小肠枯膜下集合淋巴结)中 IgA 分泌细
During both murine allogeneic and homologous pregnancies, the weight of the maternal spleen and uterine draining lymph nodes (PALN) increases during the second and third trimester of pregnancy and the number of “basal” immunoglobulin (Ig) secreting cells in these organs also increases , The increase in spleen peaked at 16 days of gestation, and peaked at 18-19 days in PALN. Increased maternal “basal” Ig secretion is induced by maternal hormones and or soluble factors from the fetus or placenta. Pregnancy test confirmed that single parent hormone can not explain this increase. Early studies by the authors have demonstrated that the placenta plays an important regulatory role in maternal Ig synthesis. In later pregnancies, IgA secretion is small in the spleen and Peyer’s knot (collection of small intestine wounded lymph nodes)