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目的了解六盘水市健康人群乙型肝炎(乙肝)表面抗体水平,评价疫苗接种效果和人群免疫状况,为制定乙肝免疫规划提供依据。方法采用分层随机抽样和简单随机抽样的方法抽取健康人群血样。采用酶联免疫吸附(ELISA)法进行乙肝表面抗体检测。结果检测2区县459份血样,抗-HBs阳性率66.01%。抗-HBs阳性率随年龄增高而降低(P<0.01),有乙肝疫苗接种史人群的抗-HBs阳性率高于无接种史人群(P<0.05)。结论六盘水市将乙肝疫苗纳入免疫规划后,人群免疫水平明显提高。
Objective To understand the level of hepatitis B (HBsAg) antibodies in healthy population of Liupanshui city and to evaluate the effect of vaccination and the immune status of the population, so as to provide basis for formulating hepatitis B immunization program. Methods Blood samples were collected from healthy people by stratified random sampling and simple random sampling. HBsAg was detected by enzyme-linked immunosorbent assay (ELISA). Results 459 blood samples were detected in 2 districts and counties, the positive rate of anti-HBs was 66.01%. The positive rate of anti-HBs decreased with age (P <0.01). The positive rate of anti-HBs in those with history of hepatitis B vaccination was higher than those in non-vaccinated history (P <0.05). Conclusions After the hepatitis B vaccine was incorporated into the immunization program in Liupanshui City, the immunization level of the population was significantly increased.