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本文介绍了药品中糖精(Saccharin)的测定方法,用N,O-双(三甲基甲硅烷基)乙酰胺使糖精硅烷化后进行气-液层析。此法比前报导的其它方法有较多的改进,如硅烷化速度快、层析前无需作任何处理、对药品制剂中其它有效成分或赋形剂等均无干扰。设备用氢火焰离子化检测器附有数字计算计的气相层析仪。层析柱为外径0.9×0.3厘米的304型不锈钢管。担体为100～120目硅烷化硅藻土(Vara-port 30)。固定相为5%三氟丙基甲基硅酮(OV-
This article describes a method for the determination of saccharin in pharmaceuticals, which is gas-liquid chromatographed with silanated saccharin using N, O-bis (trimethylsilyl) acetamide. This method than the previous report of other methods have more improvements, such as silanization speed, without any treatment prior to chromatography on the pharmaceutical preparations of other active ingredients or excipients without interference. Equipment with hydrogen flame ionization detector attached to a digital calculator gas chromatography. Column for the outer diameter of 0.9 × 0.3 cm 304 stainless steel tube. The support is 100-120 mesh Vara-port 30. 5% stationary phase Trifluoropropyl methyl silicone (OV-