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目前认为高原条件下的多尿反映是因外周化学感受器受刺激所致,其意义在于减轻心脏的容积负荷过载.我们应用灌流阿米川(0.5mg/kg,持续30分)的方法在10名健康男性身上对此假说做了进一步探讨。研究发现,阿米川可增加肺通气量,提高心率、心室收缩压及中心静脉,并促进尿中钠的排泄,但不能增加血浆心钠素浓度及产生多尿。结果表明:(1)阿米川和低氧性低氧(约5 000m高度)具有类似的作用位点,即动脉化学感受器和肺血管;(2)动脉化学感受器受刺激期间尿中钠排泄出的增加可能有助于减轻心脏的容积负荷过载;(3)为进一步阐明低氧诱发的
At present, it is thought that the polyuria in plateau is caused by stimulation of peripheral chemoreceptors, and the significance is to relieve the volume overload of the heart.We applied perfused Amikawa (0.5mg / kg for 30min) to 10 healthy This hypothesis is further explored by men. The study found that amikawa can increase pulmonary ventilation, increase heart rate, ventricular systolic pressure and central venous, and promote urinary sodium excretion, but can not increase plasma atrial natriuretic peptide concentration and produce polyuria. The results showed that: (1) Ami Chuan and hypoxic hypoxia (about 5 000 m height) have similar sites of action, namely, arterial chemokines and pulmonary vessels; (2) arterial chemoreceptors during urinary sodium excretion Increases may help reduce the volume overload of the heart; (3) To further elucidate hypoxia-induced