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硫酸小诺霉素(micronomicin Sulfas M.C.R.)又名小单孢菌素,是氨基糖甙类的广谱抗生素。与日本相模霉素(Sagamicin)系同类产品。本品主要特点是(1)抗菌范围广、耐药性小、抗菌活性强,(2)体内吸收快,分布广;(3)用药安全,其耳、肾毒性均明显低于庆大霉素。一、临床前药理研究1.抗菌作用:本品与其他氨基糖甙类抗生素相同。对革兰氏阴性菌和革兰氏阳性菌均有效。抗菌作用强,对G_+菌的最低抑菌浓度(MIC)为0.1～6.25ng/ml,对G~-菌为0.4～1.56ng/ml。2.药代动力学:肌肉吸收良好,成人肌肉注射本
Micronomycin sulfate (micronomicin Sulfas M.C.R.), also known as small spinosad, is a broad-spectrum aminoglycoside antibiotics. Similar products with Japan Sagamicin. This product is characterized by (1) a wide range of antibacterials, small resistance, strong antibacterial activity, (2) rapid absorption in the body, widely distributed; (3) medication safety, the ear, nephrotoxicity were significantly lower than gentamicin . First, the preclinical pharmacological studies 1. Antibacterial effect: The goods and other aminoglycoside antibiotics the same. Gram-negative and Gram-positive bacteria are effective. The antibacterial activity is strong, the minimum inhibitory concentration (MIC) against G_ (+) bacteria is 0.1 ~ 6.25ng / ml and 0.4 ~ 1.56ng / ml for G ~ - bacteria. 2. Pharmacokinetics: good muscle absorption, adult intramuscular injection of this