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目的:对反复早期自然流产的夫妇进行染色体分析,探讨反复早期自然流产与染色体异常的关系,为再次妊娠提供遗传咨询。方法:对1998年1月～2002年12月5年间诊断反复早期自然流产的296例夫妇,采集肘静脉血,进行淋巴细胞培养,常规方法收获细胞,低渗、固定、制片经G显带处理,行染色体核型分析。结果:染色体异常率为8.78%(26/296)。男性多于女性。结构异常25例,以平衡易位多见,大Y及臂间倒位也占相当比例;数目异常仅1例。结论:反复早期自然流产的夫妇,应常规进行染色体检查,为减少染色体病,对高龄孕妇或夫妇之一携带异常染色体的孕妇均应行产前诊断及遗传咨询。
OBJECTIVE: To analyze the relationship between spontaneous abortion and chromosomal abnormalities in early repeated spontaneous abortion to provide genetic counseling for the second pregnancy. Methods: A total of 296 couples diagnosed early spontaneous abortion from January 1998 to December 2002 were collected from the elbow venous blood and cultured in lymphocytes. The cells were harvested by conventional methods. The cells were hypotonic and fixed. Processing, lineage karyotype analysis. Results: The rate of chromosomal abnormalities was 8.78% (26/296). More men than women. Structural abnormalities in 25 cases, to balance the more common translocation, large Y and arm inversion also accounted for a considerable proportion; the number of abnormalities in only 1 case. CONCLUSION: Chromosome examination should be carried out routinely in couples with early spontaneous abortion. To reduce chromosome disease, prenatal diagnosis and genetic counseling should be performed on pregnant women with advanced age or those with abnormal chromosomes.