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目的观察鼻咽癌放疗后原发肿瘤体积的变化并分析其相关因素。方法回顾性分析46例接受放射治疗的鼻咽癌患者的临床资料,主要包括患者的年龄、性别、病理类型和生长类型、原发肿瘤体积(V0)以及放射治疗结束时残留肿瘤体积(V70)、原发肿瘤最大截面积、T分期和N分期、照射剂量等因素。采用二项分类Logistic回归分析法分析这些因素和放疗50Gy时肿瘤退缩率的关系。结果分析结果显示,肿瘤病理类型和生长类型、T分期、N分期、照射剂量与肿瘤消退有密切关系(P<0.05)。结论肿瘤体积的变化可较好的反映放疗的效果,明确肿瘤消退的相关因素,可以指导临床治疗,预后判断,提高患者生存率。
Objective To observe the changes of primary tumor volume of nasopharyngeal carcinoma after radiotherapy and analyze its related factors. Methods The clinical data of 46 patients with nasopharyngeal carcinoma undergoing radiotherapy were retrospectively analyzed. The data included age, gender, pathological type and growth type, primary tumor volume (V0) and residual tumor volume (V70) at the end of radiotherapy. , The largest cross-sectional area of primary tumor, T stage and N stage, radiation dose and other factors. Binary Logistic regression analysis was used to analyze the relationship between these factors and the tumor regression rate at 50Gy. Results of the analysis showed that tumor pathological types and growth types, T stage, N stage, irradiation dose and tumor regression are closely related (P <0.05). Conclusion The changes of tumor volume can better reflect the effect of radiotherapy, clear the relevant factors of tumor regression, can guide clinical treatment, prognosis and improve patient survival rate.