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目的观察银杏达莫注射液联合前列腺素E1和多种维生素治疗糖尿病周围神经病变(DPN)的临床疗效。方法 106例DPN患者被随机分成对照组和治疗组,每组53例。对照组采用前列腺素E1和多种维生素治疗,治疗组在对照组的基础上加用银杏达莫注射液。检测两组患者治疗前后的空腹血糖(FBG)、餐后2h血糖(2hPBS)和果糖胺(FA)以及正中神经、腓总神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV),并观察临床疗效。结果两组患者治疗前后FBG、2hPBS和FA的变化差异均无统计学意义(P均>0.05);两组患者治疗后MCV、SCV均升高,与治疗前比较差异均有统计学意义(P均<0.01),且治疗组的MCV、SCV均高于对照组(P<0.01);两组患者治疗后临床症状均改善,且治疗组总有效率高于对照组(P<0.05)。结论银杏达莫注射液联合前列腺素E1和多种维生素对DPN的治疗可取得更好的疗效。
Objective To observe the clinical efficacy of gingko Damo injection combined with prostaglandin E1 and multivitamin in the treatment of diabetic peripheral neuropathy (DPN). Methods 106 cases of DPN patients were randomly divided into control group and treatment group, each group of 53 cases. The control group was treated with prostaglandin E1 and multivitamin. The treatment group was given ginkgo dipyridamole injection on the basis of the control group. The fasting blood glucose (FBG), postprandial 2h blood glucose (2hPBS) and fructosamine (FA) and motor nerve conduction velocity (MCV) and sensory nerve conduction velocity (SCV) of the median nerve and common peroneal nerve were measured before and after treatment. And observe the clinical effect. Results There was no significant difference in the changes of FBG, 2hPBS and FA between the two groups before and after treatment (all P> 0.05). The MCV and SCV in both groups were significantly higher after treatment than those before treatment (P (All P <0.01). The MCV and SCV in the treatment group were significantly higher than those in the control group (P <0.01). The clinical symptoms of both groups were improved after treatment, and the total effective rate in the treatment group was higher than that in the control group (P <0.05). Conclusion Yinxingdamo injection combined with prostaglandin E1 and vitamins for DPN treatment can achieve better results.