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目的探讨药物滥用性头痛(MOH)患者认知功能及认知电位的变化情况。方法MOH患者(观察组)及对照组各30例,两组均进行P300、简易精神状态量表(MMSE)检测。采用SPSS 10.0软件进行数据处理,P300潜伏期、波幅比较采用t检验。结果两组P300靶刺激中P3潜伏期、波幅比较均差异有统计学意义:观察组P3潜伏期[分别为(393.70±42.60)ms]较对照组[(331.05±22.35)ms]延长,差异有统计学意义(t=7.13,P<0.05);观察组P3波幅[(3.40±2.30)u V]较对照组[(6.20±2.40)u V]明显降低,差异也有统计学意义(t=4.59,P<0.05)。两组MMSE评分比较,观察组总分、定向力、记忆力、计算力、回忆力、语言能力[(24.00±2.21)分,(8.15±0.86)分,(2.88±0.23)分,(3.07±1.04)分,(1.72±0.89)分,(8.42±1.33)分]低于对照组[分别为(27.07±2.06)分,(9.28±1.03)分,(3.01±0.26)分,(3.25±1.20)分,(1.92±0.90)分,(9.69±1.44)分],总分、定向力、语言能力评分差异有统计学意义(t=3.66,3.19,3.34;P<0.05)。结论 MOH患者存在轻度的认知功能障碍,认知电位P300为MOH患者认知功能障碍的诊断提供一客观指标。
Objective To investigate the changes of cognitive function and cognitive potential in drug abuse headache patients (MOH). Methods Thirty patients with MOH (observation group) and control group (n = 30) were enrolled in this study. P300 and MMSE were detected in both groups. Using SPSS 10.0 software for data processing, P300 latency, amplitude comparison using t test. Results There was significant difference in the latency and amplitude of P3 between the two groups in P3 stimulation: P3 latency (393.70 ± 42.60 ms) in the observation group was longer than that in the control group [(331.05 ± 22.35) ms], the difference was statistically significant (T = 7.13, P <0.05). The amplitude of P3 in the observation group [(3.40 ± 2.30) u V] was significantly lower than that in the control group [(6.20 ± 2.40) u V] <0.05). The score of MMSE in the two groups was significantly higher than that of the control group (P0.05). The score of total score, orientation force, memory, calculating power, memory and verbal ability in the observation group were significantly lower than those in the observation group [(24.00 ± 2.21), (8.15 ± 0.86), (2.88 ± 0.23) ), (1.72 ± 0.89), (8.42 ± 1.33) points lower than the control group (27.07 ± 2.06 points, 9.28 ± 1.03 points, 3.01 ± 0.26 points, 3.25 ± 1.20 points respectively) Points, (1.92 ± 0.90) points, (9.69 ± 1.44) points respectively. There were significant differences in total score, orientation ability and verbal ability score (t = 3.66,3.19,3.34; P <0.05). Conclusions MOH patients have mild cognitive dysfunction. Cognitive potential P300 provides an objective indicator for the diagnosis of cognitive dysfunction in MOH patients.