抗肿瘤抗生素阿霉素有心毒作用,特别是大剂量重复疗程时,可出现心包心肌综合征,左室机能障碍。最近临床上使用的4-表阿霉素,抗肿瘤活性不亚于阿霉素,但心毒作用较小;作者评定这两种制剂的心毒作用,观察Ⅲ期乳腺癌30例,年龄22-57岁。用阿霉素治疗15例,4-表阿霉素治疗15例,剂量30mg/m~2静注,3天为1个疗程,3-4周重复疗 Antitumor antibiotic doxorubicin has a cardiac effect, especially in high-dose repeated treatment, there may be pericardial cardiomyopathy, left ventricular dysfunction. The recent clinical use of 4-epirubicin, anti-tumor activity as inferior to doxorubicin, but less toxic; the authors assess the two drugs in the heart of the role of toxicity, observed in 30 cases of stage Ⅲ breast cancer, age 22 -57 years old. 15 cases were treated with doxorubicin, 15 cases were treated with 4-epirubicin, and the dose was 30 mg / m ~ 2 intravenously. The course of treatment was 3 days for 1 course and 3-4 weeks for repeat treatment