【摘 要】
：
Previous studies have confirmed that the number of glial fibrillary acidic protein-positive cells significantly increases during morphine tolerance.However,morp
【机 构】
：
Department of Anesthesiology,Qingdao Institute for Drug Control,Stem Cell Center
【基金项目】
：
the Natural Science Foundation of Shandong Province
论文部分内容阅读
Previous studies have confirmed that the number of glial fibrillary acidic protein-positive cells significantly increases during morphine tolerance.However,morphine tolerance is reversed with melanocortin receptor antagonists,and analgesic action is enhanced accordingly.However,these mechanisms remain unclear.In the present study,following addition of morphine to Wistar rat spinal cord astrocytes,glutamate levels in the supematant significantly increased(P
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