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目的:研究在原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)患者中,抗着丝点抗体(anticentromere anti-body,ACA)与临床表现之间的关系。方法:用间接免疫荧光法检测PBC患者血清抗核抗体(ANA)各荧光模式,比较ACA阳性和阴性患者临床表现的差别和免疫学指标的差别。结果:156例PBC患者中ACA阳性46例(25%),ACA阳性组乏力、黄疸症状少于ACA阴性组,两组间有统计学差异(P<0.05),肝功能异常症状两组间差异有统计学意义(P<0.05),ACA阳性组多于ACA阴性组。免疫学指标中,CD4+和IgM在两组间有统计学意义,ACA阳性组高于阴性组(P<0.05)。结论:ACA阳性的PBC患者临床表现隐匿,以单纯肝功能异常多见,易造成临床上漏诊。
Objective: To investigate the relationship between anticentromere anti-body (ACA) and clinical manifestations in patients with primary biliary cirrhosis (PBC). Methods: Indirect immunofluorescence assay was used to detect the fluorescence patterns of serum anti-nuclear antibody (ANA) in patients with PBC. The differences of clinical manifestations and immunological parameters between ACA positive and negative patients were compared. Results: Among 156 PBC patients, 46 (25%) had positive ACA, ACA positive group had less fatigue, jaundice symptoms were less than those with ACA negative group, there was significant difference between the two groups (P <0.05) There was statistical significance (P <0.05), ACA positive group than ACA negative group. Immunological indicators, CD4 + and IgM in the two groups were statistically significant, ACA-positive group was higher than the negative group (P <0.05). Conclusion: The clinical manifestations of ACA-positive PBC patients are occult, with abnormal liver function more common, easily lead to clinical missed diagnosis.