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颠茄酊为医院药房常用药,广泛地用于解除平滑肌痉挛和药房制剂配制。目前,对颠茄酊的质量控制,仍采用提取中和法,此法不但取样量太大,而且操作繁锁,分析时间长,结果不易准确。由于颠茄酊中莨菪硷含量甚微,本文试以酸性染料比色法测定其含量,即在磷酸盐缓冲液(PH7.5)条件下,莨菪硷可直接与溴麝香草酚兰所解离的阴离子定量络合成离子对,经氯仿萃取后,
Belladonna tincture for the hospital pharmacy commonly used drugs, widely used to relieve smooth muscle spasm and pharmacy preparation. At present, the quality control of belladonna tincture still use extraction and neutralization method, this method is not only sampling too much, and cumbersome operation, analysis of a long time, the result is not easy to accurate. As belladonna tincture of tinnitine content is very small, this paper try to determine the content of acid dye colorimetric method, that is, in the phosphate buffer solution (PH7.5) condition, scopolamine directly with bromothymol phenol blue Anion quantitative complex ion pairs, after chloroform extraction,