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隐球菌脑膜炎是艾滋病常见的并发症,常伴有高病死率,而且必需长期使用两性霉素 B 治疗。氟康唑(Fluconazole)是最近发现的一种三吡咯化合物,在体外对新型隐球菌有抗菌作用。据表明,此药对隐球菌脑膜炎的动物模型有效,而且容易穿透入脑脊液。本文报道1例艾滋病患者的隐球菌脑膜炎因两性霉索 B 治疗无效后使用氟康唑治疗获得成功。患者男性,40岁。1985年8月因隐球菌脑膜炎首次入院,最初给予静注两性霉素 B7周,同时加用5-氟胞嘧啶4周。后曾有
Cryptococcal meningitis is a common complication of AIDS, often accompanied by high case fatality, and the need for long-term use of amphotericin B treatment. Fluconazole, a recently discovered triazole compound, has antibacterial activity against Cryptococcus neoformans in vitro. It has been shown that this medicine is effective in animal models of cryptococcal meningitis and penetrates cerebrospinal fluid more easily. This article reports 1 case of AIDS patients with cryptococcal meningitis due to amphotericin B treatment fails after the use of fluconazole treatment was successful. Male patient, 40 years old. 1985 August due to cryptococcal meningitis first admission, initially given intravenous amphotericin B 7 weeks, plus 5-fluorocytosine 4 weeks. After there