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用６４Ｃｕ研究了铜在肝癌腹水小鼠中的代谢。研究结果表明，尾静脉注射的６４Ｃｕ在正常和肝癌小鼠中都先聚集在肝脏，在癌腹水小鼠肝脏中聚集的６４Ｃｕ要比正常小鼠的少，其它组织中６４Ｃｕ的分布也有一定的改变；癌细胞中的６４Ｃｕ占癌中的８５％以上。用ＳｅｐｈａｄｅｘＧ－７５柱分离小鼠肝脏匀浆物时，发现６４Ｃｕ主要与金属硫蛋白结合。在研究腹腔注射１２５Ｉ－（Ｃｄ，Ｚｎ）ＭＴ的转运时发现，在所观测的组织中，肝癌和肾脏中聚集的１２５Ｉ－ＭＴ最多。当腹腔注射后，１２５Ｉ－ＭＴ很快到达肝癌细胞中，并当腹水中１２５Ｉ－ＭＴ达到最大时，癌细胞中的１２５Ｉ－ＭＴ也最多。由此可见，１２５Ｉ－ＭＴ可以穿过癌细胞膜到达癌细胞。
The metabolism of copper in liver cancer ascites mice was studied with 64Cu. The results showed that the tail vein injection of 64Cu in normal and liver cancer mice are first gathered in the liver, ascites in the liver of mice gathered 64Cu less than normal mice, and other tissue 64Cu distribution also has some changes ; 64Cu in cancer cells accounted for more than 85% of cancers. When using a Sephadex G-75 column to separate mouse liver homogenates, 64Cu was found to bind predominantly to metallothionein. In studying the intraperitoneal 125 I- (Cd, Zn) MT transport, 125 I-MT was found to accumulate most frequently in liver and kidney in the tissues observed. After intraperitoneal injection, 125I-MT quickly reached hepatoma cells, and 125I-MT in cancer cells was also the most when 125I-MT in ascites was maximal. Thus, 125I-MT can pass through the cancer cell membrane to reach cancer cells.