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用D -半乳糖化的方法制备大鼠衰老模型 ,通过Morris水迷宫测试 ,观察巴戟素对衰老大鼠空间学习记忆力的影响 ;应用海马脑片灌流技术 ,观察巴戟素对海马突触长时程增强 (LTP)的影响。结果显示 ,巴戟素能使衰老大鼠逃避潜伏期缩短 ;原平台象限游泳时间和 4 0cm环内游泳时间明显延长 ;原平台象限游泳路径百分比增加。还可显著增强海马脑片的LTP效应 ,并呈一定的量效关系。提示巴戟素可提高衰老大鼠的空间学习、记忆能力 ,其作用可能与增强海马突触传递的LTP效应有关
The rat aging model was prepared by D-galactosylation. Morris water maze test was used to observe the effect of bashocin on spatial learning and memory in aging rats. The application of hippocampal slice perfusion technique was used to observe the effect of bashocin on hippocampus synapse length. Time-course enhancement (LTP) effects. The results showed that blase can shorten the escape latency of aging rats; swimming time in the original platform quadrant and swimming time in the 40 cm ring was significantly prolonged; the percentage of swimming paths in the original platform quadrant increased. Can also significantly enhance the LTP effect of hippocampal slices, and showed a certain dose-effect relationship. It is suggested that baicalein can improve the spatial learning and memory ability of aging rats, and its effect may be related to the enhancement of LTP effect of hippocampus synaptic transmission.