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报告465例非糖尿病人群中(NGT316人,IGT149人)高血压对糖尿病发病率的影响。调整年龄、性别影响后高血压组(n=140例)之6年糖尿病发病率为44.6%,显著高于非高血压组的19.7%(n=328例)。多因素(1ogist)回归分析显示排除空腹血糖与BMI这两个与6年糖尿病发病显著正相关的重要因素影响后高血压组较血压正常组仍有较高的糖尿病发病危险(OR=1.8,95%可信限1.03~3.21,P<0.05)。剔除服用降压药物者及未到实验终点而失访的86例后再分析结果仍显示收缩压(SBP)高者有较高的糖尿病发病危险(SBP升高20mmHg之糖尿病发病OR为1.5,95%Ci1.1~2.3,P=0.026),表明非糖尿病人群中高血压是糖尿病发病的独立预测因素。
The impact of hypertension on the incidence of diabetes was reported in 465 nondiabetic patients (NGT316, IGT149). The incidence of 6-year diabetes was 44.6% in hypertensive patients (n = 140) after adjustment for age and gender, significantly higher than 19.7% (n = 328) of non-hypertensive patients. Logistic regression analysis showed that there was a significant association between fasting blood glucose (FBG) and BMI, which was significantly positively correlated with the incidence of 6-year diabetes (P <0.05). The post-hypertension group still had a higher risk of developing diabetes than the normotensive group (OR = 1.8 , 95% confidence limit 1.03 ~ 3.21, P <0.05). Reposted elsewhere in the literature for analysis of 86 patients who lost their antihypertensive drugs and who did not reach the end of the experiment still showed a high risk of developing diabetes (SBP increased 20mmHg diabetes OR = 1.5 , 95% Ci1.1 ~ 2.3, P = 0.026), indicating that hypertension in non-diabetic population is an independent predictor of diabetes.