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目的:探讨左旋氨氯地平对高血压患者胰岛素抵抗的改善作用。方法:45例原发性高血压伴糖耐量异常患者随机分为实验组(25例)和对照组(20例)。对照组给予卡托普利治疗,实验组在卡托普利治疗基础上联合应用左旋氨氯地平,疗程均为8周。比较2组治疗前、后血压、血脂、空腹血糖、胰岛素和胰岛素抗体水平。结果:2组治疗后血压、空腹血糖、空腹胰岛素和胰岛素抗体水平均较治疗前下降(P<0.05),实验组下降优于对照组(P<0.05);2组治疗前、后血脂水平比较差异无统计学意义(P>0.05)。结论:左旋氨氯地平对高血压患者胰岛素抵抗有明显的改善作用。
Objective: To investigate the effect of levamlodipine on the improvement of insulin resistance in patients with essential hypertension. Methods: Forty-five patients with essential hypertension with impaired glucose tolerance were randomly divided into experimental group (n = 25) and control group (n = 20). The control group was treated with captopril, and the experimental group was given captopril combined with levamlodipine for 8 weeks. The blood pressure, blood fat, fasting blood glucose, insulin and insulin antibody levels were compared between the two groups before and after treatment. Results: After treatment, the blood pressure, fasting blood glucose, fasting insulin and insulin antibody levels in both groups decreased significantly (P <0.05), and decreased significantly in experimental group compared with those in control group (P <0.05). The levels of blood lipid in the two groups before and after treatment The difference was not statistically significant (P> 0.05). Conclusion: L-amlodipine can significantly improve the insulin resistance in patients with hypertension.