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用TAMair微量热仪测定了新合成的稀土水杨酸硫代脯氨酸配合物RE(Hsal)2·(tch)·2H2O(RE=La,Sm;Hsal=C7H5O3;tch=C4H6NO2S)在37.00℃时对大肠杆菌作用的产热曲线;根据产热曲线计算了在稀土水杨酸硫代脯氨酸配合物作用下,大肠杆菌生长代谢的最大发热功率Pmax、速率常数k、传代时间tG、抑制率I和半抑制浓度cI,50等热动力学参数.结果表明:稀土水杨酸硫代脯氨酸配合物在低浓度下对大肠杆菌有刺激作用,高浓度下为抑制作用,即稀土配合物对微生物的生长具有双向生物效应,也称为Hormesis效应.配合物Sm(Hsal)2·(tch)·2H2O(cI,50=1.62mg·L-1)的抑制效果优于La(Hsal)2·(tch)·2H2O(cI,50=7.60mg·L-1).
The new synthesis of rare earth salicylic acid thioproline complex RE (Hsal) 2 · (tch) · 2H2O (RE = La, Sm; Hsal = C7H5O3; tch = C4H6NO2S) was measured by TAMair microcalorimetry at 37.00 ℃ The heat production curve of Escherichia coli was calculated. According to the heat production curve, the maximal heating power Pmax, rate constant k, passage time tG of Escherichia coli under the action of rare earth salicylic acid thioproline complex were calculated. Rate I and semi-inhibitory concentration cI, 50 and other thermodynamic parameters.The results showed that rare earth salicylic acid thioproline complex at low concentrations of Escherichia coli stimulating effect at high concentrations for the inhibition, that rare earth complexes The biocompatibility of the compound Sm (Hsal) 2 · (tch) · 2H2O (cI, 50 = 1.62 mg · L -1) is better than that of La (Hsal) 2 · (tch) · 2H2O (cI, 50 = 7.60 mg · L -1).