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Background The percutaneous transcatheter closure of secundum atrial septal defect (ASD) is increasingly a widespread alternative to surgical closure.The aim of this study was to assess long-term results of percutaneous closure of secundum-type atrial septal defect (ASD Ⅱ).Methods Between January 2001 and December 2005,61 patients underwent a successful percutaneous closure of ASD Ⅱ; including 25 male and 36 female.All were included in the patient study and were followed up to monitor by electrocardiogram and echocardiography,at intervals of 3 days,3 months,6 months,1 year,2 years,and 5 years after operation.Results Three days after percutaneous transcatheter septal closure (PTSC),the right atrium diameter,right ventricular end-diastolic left-right diameter and right ventricutar end-diastolic volume (RVEDV) decreased significantly (P ＜0.05).Right ventricular end-diastolic anteroposterior diameter (RVEDD),right ventricular end-systolic volume (RVESV) and right ventricular ejection fraction (RVEF) also decreased (P＜0.01).During the period from 3 to 6 months,the size of the right atrium and right ventricle returned to normal range.Three days after PTSC,the left ventricular end-diastolic diameter (LVEDD),left ventricular end-diastolic volume (LVEDV),left ventricular end-systolic volume (LVESV),left ventricular-systolic volume (LVSV) and left ventricular ejection fraction (LVEF) were significantly increased (P ＜0.05).At 1 year,the size of the left atrium,left ventricle and left cardiac function returned to normal range (P ＜0.01).There were no deaths or significant complications during the study.At five year follow-up,all defects were completely closed and remained closed thereafter.Conclusion Transcatheter closure of ASD Ⅱ effectively eliminated the abnormal shunt and,subsequently improved the dimensions of each chamber and cardiac function.