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目的 探讨将兔胎仔部分取出宫腔外 ,制作动物模型的可行性及方法。方法 取 16只日本长耳大白兔孕兔 ,体重 2 .6~ 4 .0kg ,于孕 2 2d行宫内手术 ,每只母兔选一远离子宫颈的胎仔 ,将其部分取出宫腔外 ,切除一侧下腹壁皮肤、皮下及部分肌肉组织后 ,放回子宫。术后密切观察母兔有无流产 ,术后第 8d以剖宫产方式取出胎仔 ,观察手术胎仔的存活情况。结果 16只母兔 ,2只术后 1d内死于气温过高。其余 14只母兔均存活至妊娠足月 ,无一流产。 14只手术胎仔在剖宫产时存活 9只。手术胎仔存活率 6 4 .3%。结论 通过本实验方法 ,将兔胎仔部分取出宫腔外手术 ,制作相对复杂的动物模型是可行的。
Objective To investigate the feasibility and method of animal model by partially removing rabbit fetus from the uterine cavity. Methods Twenty-six Japanese white-haired rabbits with a body weight of 2.6 ~ 4.0 kg were enrolled in this study. Intrauterine surgery was performed on the 2nd and 2nd feces of pregnant women. Each females selected a fetus away from the cervix and removed some of them from the uterine cavity. Side of the lower abdominal skin, subcutaneous and some muscle tissue, back into the uterus. After operation, the female rabbits were closely observed for abortion. The fetal fetus was removed by cesarean section on the 8th day after operation and the survival of the surgical fetus was observed. Results Sixteen female rabbits, two died within 1 day after operation, were over-temperatured. The remaining 14 females survived until full-term pregnancy without abortion. Fourteen surgical fetuses survived 9 at cesarean section. Surgery fetal survival rate of 6.43%. Conclusions It is feasible to make a relatively complicated animal model by partially removing the fetus from the uterine cavity by this experimental method.