1979年,龚忠恕(P.C.Kung)和Golds-tein等首次报道抗人T细胞单克隆抗体(Mc~-Ab)OKT系列制备成功。其中,OKT3与大约70％正常人外周血单个核细胞(PBM)反应,识别全部T细胞;OKT4与40％～50％正常人PBM反应,识别诱导和辅助T细胞亚群(Ti/h);OKT8与20％～30％正常人PBM反应,识别杀伤和抑制性T细胞亚群(T_(C/S)。此后,又有许多其它抗人T细胞 In 1979, P.C.Kung and Golds-tein first reported the success of the OKT series of anti-human T cell monoclonal antibody (Mc ~ -Ab). Among them, OKT3 reacts with about 70% of normal human peripheral blood mononuclear cells (PBM) to recognize all T cells; OKT4 reacts with 40% to 50% of normal PBMs to recognize induced and helper T cell subsets (Ti / h); OKT8 reacts with PBM from 20% to 30% of normal individuals and recognizes the T_ (C / S) of killer and inhibitory T cell subsets. Since then, many other anti-human T cells