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目的:探讨急性非ST段抬高性心肌梗死(NSTEMI)患者血清尿酸水平与N末端B型钠尿肽原(NT-pro BNP)的相关性分析。方法:将143例NSTEMI患者按照入院时血清尿酸四分位数分为四组:Ⅰ组(尿酸<284.18μmol/L)、Ⅱ组(284.19~336.53μmol/L),Ⅲ组(336.54~390.78μmol/L),Ⅳ(尿酸>390.79μmol/L);按照血清NT-pro BNP中位数分为2组:NT-pro BNP<571.56 pg/m L组和NT-pro BNP≥571.56 pg/m L组;比较各组相关指标的差异。结果:Ⅰ组、Ⅱ组、Ⅲ组及Ⅳ组四组的NT-pro BNP、GRACE危险评分、CK-MB、LEVF、c Tn I比较统计学差异(P<0.05),Ⅳ组NT-pro BNP、GRACE危险评分、c Tn I、CK-MB高于Ⅰ组、Ⅱ组、Ⅲ组,Ⅲ组高于Ⅰ组、Ⅱ组(P<0.05);NT-pro BNP≥571.56 pg/m L组血清尿酸、GRACE危险评分、c Tn I、CK-MB高于NT-pro BNP<571.56pg/m L组(P<0.05)。血清尿酸分别与NT-pro BNP、GRACE危险评分呈现正相关(P<0.05)。结论:血清尿酸水平与NSTEMI患者的NT-pro BNP密切相关,临床检测血清尿酸水平对于评估NSTEMI患者NT-pro BNP水平具有重要的意义。
Objective: To investigate the relationship between serum uric acid level and N-terminal pro-brain natriuretic peptide (NT-pro BNP) in patients with acute non-ST-segment elevation myocardial infarction (NSTEMI). Methods: One hundred and seventy-three patients with NSTEMI were divided into four groups according to the serum uric acid quartile on admission: group Ⅰ (uric acid <284.18μmol / L), group Ⅱ (284.19-336.53μmol / L), group Ⅲ (336.54-390.78μmol / L), Ⅳ (uric acid> 390.79μmol / L). According to the median of serum NT-pro BNP, there were 2 groups: NT-pro BNP <571.56 pg / m L and NT-pro BNP≥571.56 pg / Group; compare the differences between the relevant indicators in each group. Results: The NT-pro BNP, GRACE risk score, CK-MB, LEVF and c Tn I in group Ⅰ, group Ⅱ, group Ⅲ and group Ⅳ were significantly different (P <0.05) , GRACE risk score, cTn I, CK-MB were higher than those in group Ⅰ, Ⅱ, Ⅲ, Ⅲ were higher than those in group Ⅰ and Ⅱ (P <0.05); NT-pro BNP≥571.56 pg / Uric acid, GRACE risk score, cTn I, CK-MB were higher than those of NT-pro BNP <571.56pg / m L group (P <0.05). Serum uric acid was positively correlated with NT-pro BNP and GRACE risk score (P <0.05). Conclusion: Serum uric acid level is closely related to NT-pro BNP in patients with NSTEMI. The clinical detection of serum uric acid level is of great significance in assessing the level of NT-pro BNP in patients with NSTEMI.