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目的 :评价国产重组人类促红细胞生成素 (rh EPO)防治极低出生体重儿 (VLBW)贫血的效果和安全性。方法 :30例 VL BW随机分为治疗组及对照组各 1 5例。治疗组用国产 rh EPO750 IU· kg-1·周 -1 ,每周分 3次皮下注射 ,共 6周 ;对照组未用 rh EPO治疗。两组 VLBW同时补充铁剂 ,根据输血指征必要时予红细胞输注。观察两组 VLBW的血液学参数、输血率及输血量、热卡摄入、体重增长等指标。结果 :治疗组用药后血清促红细胞生成素 (EPO)极显著高于对照组 (P<0 .0 1 ) ;治疗组血红蛋白 (Hb)、红细胞压积 (Hct)、网织红细胞 (Ret)均极显著高于对照组 (P<0 0 1 ) ;治疗组的输血率较对照组明显减少 (P<0 .0 5) ;血清铁蛋白 (SF)水平在用药后治疗组极明显低于对照组 (P<0 .0 0 1 )。观察期间 ,治疗组的体重增长指标较对照组高 (P<0 .0 5)。结论 :国产 rh EPO能有效提高 VLBW的 Hb、 Hct、 Ret,减轻VLBW贫血 ,且用药安全 ,无明显副作用
Objective: To evaluate the efficacy and safety of domestic recombinant human erythropoietin (rh EPO) in the prevention and treatment of very low birth weight infants (VLBW) anemia. Methods: Thirty (30) cases of VL BW were randomly divided into treatment group (15 cases) and control group (15 cases). The treatment group with domestic rh EPO750IU · kg-1 · weeks -1, subcutaneous injection 3 times a week for 6 weeks; control group without rh EPO treatment. Both groups of VLBW were given iron supplements at the same time, and red blood cells were infused when necessary according to the indication of blood transfusion. Observed the two groups of VLBW hematology parameters, blood transfusion and blood transfusion, calorie intake, weight gain and other indicators. Results: The levels of serum erythropoietin (EPO) in the treatment group were significantly higher than those in the control group (P <0.01). The levels of hemoglobin, hematocrit and reticulocyte in the treatment group were significantly higher than those in the control group (P <0.01). The blood transfusion rate in the treatment group was significantly lower than that in the control group (P <0.05). The serum ferritin (SF) level in the treatment group was significantly lower than that in the control group Group (P <0. 0 0 1). During the observation period, the weight gain index of the treatment group was higher than that of the control group (P <0.05). Conclusion: Domestic rh EPO can effectively improve the Hb, Hct, Ret of VLBW and reduce the VLBW anemia, and the drug is safe and has no obvious side effects