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目的:评价液基细胞学联合人乳头状瘤病毒-DNA检测对宫颈癌筛查的作用。方法:采用液基细胞学联合HPV筛查方法和宫颈活检方法对宫颈鳞状上皮内高度病变(HSIL,CINⅡ-Ⅲ)和鳞状细胞癌(SCC)进行筛查,比较两种方法的筛查准确性。结果:液基细胞学共筛查2 596例,与宫颈活检诊断符合率:SCC 100.0%(10/10);HSIL 79.5%(35/44);LSIL 54.2%(32/59);ASCUS 63.1%(53/84)。HPV16,18感染表现随宫颈病变加重而逐渐升高。结论:液基细胞学联合HPV-DNA检测对宫颈癌的筛查准确性高,是一种较为理想的宫颈癌筛查方法。
Objective: To evaluate the effect of liquid-based cytology combined with human papillomavirus-DNA test on cervical cancer screening. Methods: Cervical squamous intraepithelial neoplasia (HSIL, CINⅡ-Ⅲ) and squamous cell carcinoma (SCC) were screened by liquid-based cytology combined with HPV screening and cervical biopsy. Two screening methods were compared accuracy. Results: A total of 2 596 cases were screened by liquid-based cytology. The coincidence rate with cervical biopsy was 100.0% (10/10) for SCC, 79.5% (35/44) for HSIL, 54.2% (32/59) for LSIL, 63.1% (53/84). HPV16, 18 infection with cervical lesions increased and gradually increased. Conclusion: Liquid-based cytology combined with HPV-DNA detection of cervical cancer screening accuracy is high, is an ideal screening method for cervical cancer.