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本文利用我院在国内首先建立的人尿Tamm-Horsfall糖蛋白(THP)放免测定方法对肾脏病患者111例进行检测,发现急、慢性肾衰尿THP值降低最显著,其次为原发性肾小球疾病、狼疮性肾炎;肾病综合征轻度降低;紫癜性肾炎、尿路感染与正常人无差异。肾脏疾病中内生肌酐清除率(Ccr)<50ml/min的患者与尿THP呈正相关;Ccr51～75ml/min与尿THP呈非常显著负相关,Ccr>75ml/min与THP无相关性。组织学分型的尿THP分析显示了肾脏远曲肾小管的病损程度。
In this paper, the first established in our hospital human urinary Tamm-Horsfall glycoprotein (THP) radioimmunoassay detection of 111 cases of kidney disease patients were detected, acute and chronic renal failure found the most significant reduction of THP, followed by primary kidney Glomerular disease, lupus nephritis; mild nephrotic syndrome decreased; purpura nephritis, urinary tract infection and no difference in normal subjects. Renal disease endogenous creatinine clearance (Ccr) <50ml / min in patients with urinary THP was positively correlated; Ccr51 ~ 75ml / min and urine THP showed a very significant negative correlation, Ccr> 75ml / min and THP no correlation. Histological typing of urinary THP analysis showed the degree of renal distal flexor tubule lesions.