目的　研究 Ｂｃｌ２ 和 Ｂａｘ 蛋白与人脑星形细胞瘤发生的关系。方法　收集人脑星形细胞瘤标本５８ 例， 行 Ｓ Ｐ 染色。结果　 Ｂｃｌ２ 在星形细胞瘤中阳性表达率为５６９ ％ ， 且表达率随肿瘤恶性程度的增加而增高。 Ｂａｘ 的表达率为５５２ ％ ， 显著高于对照组。 Ｂｃｌ２ 表达阳性的肿瘤中 Ｂａｘ 蛋白表达率（６６７ ％ ） 显著高于 Ｂｃｌ２ 表达阴性的肿瘤（４００ ％ ） 。结论　 Ｂｃｌ２ 和 Ｂａｘ 蛋白的表达与星形细胞瘤的发生和发展有较密切的关系， 且它们在星形细胞瘤的发生中可能存在相互作用的关系。 Objective To study the relationship between Bcl2 and Bax protein and the occurrence of human astrocytoma. Methods Fifty-eight human astrocytoma samples were collected and stained with SP. Results The positive rate of Bcl2 in astrocytoma was 569%, and the expression rate of Bcl2 increased with the malignant degree of tumor. The expression rate of Bax was 552%, which was significantly higher than that of the control group. The expression of Bax in Bcl2positive tumors (667%) was significantly higher than that in Bcl2-negative tumors (400%). Conclusions The expression of Bcl2 and Bax proteins is closely related to the occurrence and development of astrocytomas, and they may have an interaction in the development of astrocytoma.