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目的探讨不同手术方式在胃癌侵及胰头十二指肠患者中的手术治疗效果差异。方法胃癌侵及胰头和十二指肠患者共60例,分为观察组(36例)和对照组(24例)。观察组实施根治性手术,对照组实施姑息性手术。观察两组患者术后12、24、48个月的生存情况;观察两组患者术后并发症(吻合口瘘、急性胰腺炎、肠瘘、感染等)发生情况;对患者术前和术后12个月的应用状况进行检测,检测白蛋白、转铁蛋白水平改变情况。结果观察组术后并发症发生率为19.4%;对照组术后并发症发生率为16.7%;观察组术后并发症发生率和对照组比较,差异无统计学意义(P>0.05)。观察组术后24、48个月生存率分别高于同期对照组生存率,差异有统计学意义(P<0.05)。观察组患者术后12个月白蛋白、转铁蛋白水平分别高于对照组术后同期水平,差异有统计学意义(P<0.05)。结论胃癌侵及胰头十二指肠的根治性手术能够提高患者生存率,减少术后并发症,改善患者生存质量,效果显著。
Objective To investigate the difference of surgical treatment effect between different surgical methods in patients with gastric cancer invading pancreaticoduodeneal duodenum. Methods A total of 60 patients with gastric cancer invading the head of pancreas and duodenum were divided into observation group (36 cases) and control group (24 cases). The observation group underwent radical surgery and the control group underwent palliative surgery. The survival of the two groups were observed at 12, 24 and 48 months after operation. The incidence of postoperative complications (anastomotic fistula, acute pancreatitis, intestinal fistula, infection, etc.) in both groups were observed. 12 months of application of detection, detection of albumin, transferrin level changes. Results The incidence of postoperative complications in the observation group was 19.4%. The incidence of postoperative complications in the control group was 16.7%. The incidence of postoperative complications in the observation group was not significantly different from that in the control group (P> 0.05). Survival rates of the observation group at 24 and 48 months after operation were higher than those of the control group at the same period, the difference was statistically significant (P <0.05). The levels of albumin and transferrin in observation group at 12 months after operation were significantly higher than those in control group at the same period after operation (P <0.05). Conclusion The radical operation of gastric cancer invading the duodenum of the pancreas can improve the survival rate of patients, reduce the postoperative complications and improve the quality of life of patients with significant effect.