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目的了解四川省2006-2016年猪链球菌血清2型菌株的分子流行病学特征,分析10年间分离株之间的关联,为四川省人感染猪链球菌病防控提供参考依据。方法通过聚合酶链反应法扩增猪链球菌基因组上的7个管家基因片段并进行测序,对2006-2016年四川省猪链球菌病例样本中分离的27株猪链球菌血清2型菌株进行多位点序列分型分析。结果 27株猪链球菌血清2型菌株分为2个ST型,其中19株为ST7型,其余为ST1型;2006-2007年以ST7型为主,2007年后主要为ST1型。结论近年四川省人感染猪链球菌病均为散发,未出现暴发疫情,可能与流行菌株的ST型变化相关。
Objective To understand the molecular epidemiological characteristics of Streptococcus suis serotype 2 strains from 2006 to 2016 in Sichuan Province and to analyze the correlation between isolates in 10 years and to provide a reference for the prevention and control of Streptococcus suis infection in Sichuan Province. Methods Seven housekeeping gene fragments of Streptococcus suis were amplified by polymerase chain reaction and sequenced. A total of 27 Streptococcus suis serotype 2 isolates were isolated from cases of Streptococcus suis in Sichuan Province from 2006 to 2016 Site sequence typing analysis. Results 27 Streptococcus suis serotype 2 isolates were divided into two ST types, of which 19 were ST7 type and the rest were ST1 type. ST7 type was the main type from 2006 to 2007, and ST1 type mainly after 2007. Conclusion In recent years, people in Sichuan province have been infected with Streptococcus suis, which did not appear outbreak, which may be related to the ST type of the epidemic strains.