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目的观察糖肾宁方对早期糖尿病肾病患者尿蛋白及尿足细胞的影响。方法 70例早期糖尿病肾病患者随机分为对照组(34例)和治疗组(36例),两组均给予西医基础治疗,对照组另予DM120方,治疗组予以糖肾宁方,疗程12周。观察并比较两组患者24h尿蛋白定量、尿足细胞计数、尿podocin和尿nephrin的变化。结果第12周,治疗组患者的24h尿蛋白定量降低(P<0.01),尿足细胞计数减少(P<0.01),尿podocin和尿nephrin亦降低(P<0.05或P<0.01);且治疗组第12周的24h尿蛋白定量、尿足细胞podocin的差值均低于同期对照组(P<0.05)。结论糖肾宁方能降低早期DKD患者尿蛋白的排泄,其作用机理可能与减轻足细胞的损伤有关。
Objective To observe the effect of Tangshenning Decoction on urinary protein and urinary podocyte in patients with early diabetic nephropathy. Methods Seventy patients with early diabetic nephropathy were randomly divided into control group (n = 34) and treatment group (n = 36). Both groups were treated with western medicine and the control group with DM120. The treatment group was treated with Tangshenning Decoction for 12 weeks . The urinary protein excretion, urinary podocyte count, urine podocin and urinary nephrin were observed and compared between two groups. Results At the 12th week, the urinary protein excretion of 24h in treatment group was decreased (P <0.01), the number of urinary podocyte was decreased (P <0.01), urinary podocin and urinary nephrin were also decreased (P <0.05 or P <0.01) The difference of 24h urinary protein and podocin of urinary podocyte in group 12 was lower than that in the same period (P <0.05). Conclusion Tangshenning Decoction can reduce urinary protein excretion in patients with early DKD, its mechanism may be related to the reduction of podocyte injury.