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目的：研究类ＮＩＤＤＭ大鼠模型肝糖原合成酶的活性。方法：雄性Ｗｉｓｔａｒ大鼠４０只，随机分为两组，每组２０只，一组用小剂量链脲佐菌素（ＳＴＺ，３０ｍｇ／ｋｇ）尾静脉注射，另一组不给ＳＴＺ，作为对照组，观察１８周，选择糖耐量异常、胰岛素水平高于或等于对照组者作为类ＮＩＤＤＭ大鼠模型，实验末期测定其肝糖原合成酶的活性。结果：Ⅰ型酶为（０．１８±０．０６）μｍｏｌ／（ｍｉｎ·ｇ）相对于（０．２４±０．０９）μｍｏｌ／（ｍｉｎ·ｇ）（Ｐ＜０．０５），而总酶Ｉ＋Ｄ为（１．５±０．４）μｍｏｌ／（ｍｉｎ·ｇ）相对于（１．８±０．４）μｍｏｌ／（ｍｉｎ·ｇ）（Ｐ＜０．０５）。结论：糖尿病鼠此酶活性明显低于对照组。
PURPOSE: To study the activity of glycogen synthase in a NIDDM-like rat model. Methods: Forty male Wistar rats were randomly divided into two groups (20 rats in each group). One group was injected with STZ (30mg / kg) into the tail vein and the other group was not given STZ. Group. After 18 weeks of observation, patients with impaired glucose tolerance and insulin level higher than or equal to that of the control group were selected as the NIDDM-like rat model. The activity of glycogen synthase was measured at the end of the experiment. Results: The activity of type Ⅰ enzyme was (0.18 ± 0.06) μmol / (min · g) vs (0.24 ± 0.09) μmol / (min · g) (P <0.05) Enzyme I + D was (1.5 ± 0.4) μmol / (min · g) versus (1.8 ± 0.4) μmol / (min · g) (P <0.05). Conclusion: The enzyme activity of diabetic rats was significantly lower than that of the control group.